Adreno-leukodystrophy: oxidative stress of mice and men.

  title={Adreno-leukodystrophy: oxidative stress of mice and men.},
  author={J Michael Powers and Zhengtong Pei and Ann K Heinzer and Rebecca Deering and Ann Moser and Hugo W. Moser and Paul A. Watkins and Kirby D. Smith},
  journal={Journal of neuropathology and experimental neurology},
  volume={64 12},
X-linked adreno-leukodystrophy is a progressive, systemic peroxisomal disorder that affects primarily nervous system myelin and axons as well as the adrenal cortex. Several divergent clinical phenotypes can occur in the same family; thus, there is no correlation between the clinical phenotype and the mutation in the ABCD1 gene in this disease. The most urgent and unresolved clinical issue is the fulminant inflammatory (immune) demyelination of the central nervous system in which a variety of… CONTINUE READING
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