Adrenergic stimulation of hepatocyte growth factor expression.

  title={Adrenergic stimulation of hepatocyte growth factor expression.},
  author={J Broten and George Michalopoulos and Bryon Petersen and Jennifer L. Cruise},
  journal={Biochemical and biophysical research communications},
  volume={262 1},
Hepatocyte growth factor (HGF), a potent mitogen, is released into plasma at increased levels following injury to certain tissues, including the liver. Early increases in plasma HGF are not due to a release from the injured liver, but rather from distal organs, particularly the lung. We have investigated the ability of norepinephrine (NE), which rises rapidly in plasma after liver resection, to trigger elevated production of HGF in MRC-5 human embryonic lung fibroblasts. Levels of HGF released… CONTINUE READING

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