Adrenergic stimulation decreases osteoblast oxytocin synthesis

@article{Cuscito2011AdrenergicSD,
  title={Adrenergic stimulation decreases osteoblast oxytocin synthesis},
  author={Concetta Cuscito and Graziana Colaianni and Roberto Tamma and Giovanni Greco and Stefania Dell'endice and Tony Yuen and Li Sun and Mone Zaidi and Adriana Di Benedetto and Alberta Zambonin Zallone},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1237}
}
Oxytocin (OT) regulates bone mass by inducing the differentiation of osteoblasts to a mature, mineralizing phenotype. We have shown recently that osteoblasts can synthesize OT. In view of known interactions between OT‐ergic and adrenergic neurons in the central nervous system, we questioned whether the negative regulation of osteoblast differentiation by adrenergic nerves was mediated through its suppression of OT synthesis. We first confirmed that α1b and β2 adrenergic receptors were expressed… Expand
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