Adrenergic regulation of the force-frequency effect

  title={Adrenergic regulation of the force-frequency effect},
  author={John Ross},
  journal={Basic Research in Cardiology},
An important interaction between β-adrenergic receptor (AR) stimulation and the myocardial contractile response to increased heart rate has only recently been identified. The effect of β-AR stimulation to amplify the force-frequency effect is responsible for a large component of the positive inotropic effect of exercise in conscious dogs and also can be demonstrated at rest with dobutamine infusions over a range of paced heart rates. The interaction is apparent across species (dog, pig, mouse… CONTINUE READING
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Effects of a sinus node inhibitor on the normal and failing rabbit heart

  • Ryu K-H, N Tanaka, Ross J
  • Basic Res Cardiol
  • 1996

Adrenergic responses and the descending limb of force-frequency relations in the failing rabbit heart

  • Ryu K-H, N Tanaka, N Dalton, Ross J
  • 1995

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