Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.

@article{Rank2011AdrenergicRM,
  title={Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.},
  author={Michelle M. Rank and Katherine C. Murray and Marilee J. Stephens and Jessica D'Amico and Monica A. Gorassini and David J. Bennett},
  journal={Journal of neurophysiology},
  year={2011},
  volume={105 1},
  pages={410-22}
}
The brain stem provides most of the noradrenaline (NA) present in the spinal cord, which functions to both increase spinal motoneuron excitability and inhibit sensory afferent transmission to motoneurons (excitatory postsynaptic potentials; EPSPs). NA increases motoneuron excitability by facilitating calcium-mediated persistent inward currents (Ca PICs) that are crucial for sustained motoneuron firing. Spinal cord transection eliminates most NA and accordingly causes an immediate loss of PICs… CONTINUE READING
Highly Cited
This paper has 77 citations. REVIEW CITATIONS
22 Citations
91 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

77 Citations

01020'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 77 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 91 references

Inhibitory control from the brainstem of transmission from primary afferents to motoneurons , primary afferent terminals and ascending pathways

  • A Lundberg
  • Brain Stem Control of Spinal Mechanisms , edited…
  • 1982
Highly Influential
5 Excerpts

Motoneuron excitability and muscle 885 spasms are regulated by 5 - HT 2 B and 5 - HT 2 C receptor activity

  • K Murray, MJ Stehens, EW Ballou, CJ Heckman, DJ Bennett
  • Journal of Neurophysiology in preparation , 886
  • 2010
Highly Influential
4 Excerpts

Recovery of motoneu - ron and locomotor function after spinal cord injury depends on constitutive activity in 5 - HT ( 2 C ) receptors

  • KC Murray, A Nakae, +14 authors K Fouad
  • Nat Med
  • 2010
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…