Adrenergic receptor stimulation attenuates insulin-stimulated glucose uptake in 3T3-L1 adipocytes by inhibiting GLUT4 translocation.

@article{Mulder2005AdrenergicRS,
  title={Adrenergic receptor stimulation attenuates insulin-stimulated glucose uptake in 3T3-L1 adipocytes by inhibiting GLUT4 translocation.},
  author={Alexandra H. Mulder and Cees J. Tack and Andr{\'e} J. Olthaar and Paul Smits and Fred C G J Sweep and Remko R. Bosch},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2005},
  volume={289 4},
  pages={
          E627-33
        }
}
  • A. Mulder, C. Tack, +3 authors R. Bosch
  • Published 1 October 2005
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Activation of the sympathetic nervous system inhibits insulin-stimulated glucose uptake. However, the underlying mechanisms are incompletely understood. Therefore, we studied the effects of catecholamines on insulin-stimulated glucose uptake and insulin-stimulated translocation of GLUT4 to the plasma membrane in 3T3-L1 adipocytes. We found that epinephrine (1 microM) nearly halved insulin-stimulated 2-deoxyglucose uptake. The beta-adrenoceptor antagonist propranolol (0.3 microM) completely… 
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