Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.

@article{Bogaard2010AdrenergicRB,
  title={Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats.},
  author={Harm Jan Bogaard and Ramesh Natarajan and Shiro Mizuno and Antonio Abbate and Philip J Chang and Vinh Q. Chau and Nicholas N. Hoke and Donatas Kraskauskas and Michael Kasper and Fadi N. Salloum and Norbert Felix Voelkel},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={182 5},
  pages={652-60}
}
RATIONALE Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolic heart failure, but is not used in PAH. OBJECTIVES To assess the effect of the adrenergic receptor blocker carvedilol on the pulmonary circulation and right heart in experimental pulmonary hypertension in rats. METHODS Angioproliferative pulmonary hypertension was induced in rats by combined… CONTINUE READING