Adrenergic receptor activation involves ATP release and feedback through purinergic receptors.

@article{Sumi2010AdrenergicRA,
  title={Adrenergic receptor activation involves ATP release and feedback through purinergic receptors.},
  author={Yuka Sumi and Tobias Woehrle and Yan Chen and Yongli Yao and Andrew X. Li and Wolfgang G. Junger},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={299 5},
  pages={C1118-26}
}
Formyl peptide receptor-induced chemotaxis of neutrophils depends on the release of ATP and autocrine feedback through purinergic receptors. Here, we show that adrenergic receptor signaling requires similar purinergic feedback mechanisms. Real-time RT-PCR analysis revealed that human embryonic kidney (HEK)-293 cells express several subtypes of adrenergic (α(1)-, α(2)-, and β-receptors), adenosine (P1), and nucleotide receptors (P2). Stimulation of G(q)-coupled α(1)-receptors caused release of… CONTINUE READING
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protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways

  • LA Selbie, SJ GHill
  • Trends Pharmacol Sci
  • 1998
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