Adrenergic mediation of TNF alpha-stimulated ICAM-1 expression on human brain microvascular endothelial cells.

@article{Ohara2000AdrenergicMO,
  title={Adrenergic mediation of TNF alpha-stimulated ICAM-1 expression on human brain microvascular endothelial cells.},
  author={Yuichi Ohara and Richard M. McCarron and Tim Hoffman and Hisashi Sugano and Joliet Bembry and Fred Lenz and Maria Spatz},
  journal={Acta neurochirurgica. Supplement},
  year={2000},
  volume={76},
  pages={117-20}
}
Adrenergic innervation derived from locus ceruleus has been implicated in regulating BBB permeability and inflammatory responses associated with neurological disorders. This report demonstrates that adrenergic agents attenuate the tumor necrosis factor-alpha (TNF alpha)-induced expression of intercellular adhesion molecule-1 (ICAM-1) on cerebral microvascular endothelial cells (HBMEC) derived from human brains. HBMEC were incubated with isoproterenol (1-10 microM) alone or in the presence of… CONTINUE READING