Adrenergic influences on histamine-mediated bronchoconstriction in the guinea pig.

@article{Drazen1978AdrenergicIO,
  title={Adrenergic influences on histamine-mediated bronchoconstriction in the guinea pig.},
  author={Jeffrey M Drazen},
  journal={Journal of applied physiology: respiratory, environmental and exercise physiology},
  year={1978},
  volume={44 3},
  pages={340-5}
}
Intravenous infusion of histamine results in a fall in dynamic pulmonary compliance (Cdyn) in the unanesthetized guinea pig. During a prolonged infusion of histamine (30-200 s) a minimum value of Cdyn is reached and sustained after 30 s. Propranolol (10 mg/kg) enhanced this steady-state response in both normal and adrenally ablated guinea pigs to the same… CONTINUE READING