Adrenergic control of lipogenesis and lipolysis in the chicken in vitro.

Abstract

The adrenergic inhibition of lipogenesis and stimulation of lipolysis in the avian has been examined using chicken hepatocytes and adipose tissue explants in vitro. Lipogenesis was inhibited by adrenergic agonists: epinephrine (alpha + beta) greater than isoproterenol (beta 1/beta 2) greater than norepinephrine (alpha 1/alpha 2, beta 1) greater than metaproterenol (beta 2), phenylephrine (alpha 1). Dobutamine (beta 1 agonist) and dopamine (dopaminergic agonist) did not significantly affect [14C]acetate incorporation into lipid, while clonidine and para-aminoclonidine (alpha 2 agonists) were slightly stimulatory. Lipolysis in young and adult chicken adipose tissue was stimulated by epinephrine, isoproterenol, phenylephrine, dobutamine and metaproterenol, but was inhibited by clonidine and para-aminoclonidine. Both the antilipogenic and lipolytic effects of epinephrine were partially blocked by phentolamine (alpha 1 = alpha 2 antagonist) or propranolol (beta 1 = beta 2 antagonist), but completely inhibited by phentolamine and propranolol administered together.

Statistics

0200400'95'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

55 Citations

Semantic Scholar estimates that this publication has 55 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Campbell1985AdrenergicCO, title={Adrenergic control of lipogenesis and lipolysis in the chicken in vitro.}, author={Rosa M. Campbell and Colin G. Scanes}, journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology}, year={1985}, volume={82 1}, pages={137-42} }