Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics.

  title={Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics.},
  author={Donald C Simonson and Veikko Koivisto and Robert S. Sherwin and Ele Ferrannini and Rosa E Hendler and Anders Juhlin-Dannfelt and Ralph A DeFronzo},
  journal={The Journal of clinical investigation},
  volume={73 6},
We investigated the effects of alpha and/or beta adrenergic blockade (with phentolamine and/or propranolol) on glucose homeostasis during exercise in six normal subjects and in seven Type I diabetic subjects. The diabetics received a low dose insulin infusion (0.07 mU/kg X min) designed to maintain plasma glucose at approximately 150 mg/dl. In normals, neither alpha, beta, nor combined alpha and beta adrenergic blockade altered glucose production, glucose uptake, or plasma glucose concentration… CONTINUE READING


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Publications referenced by this paper.
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Disparate effect of beta - blockade on the hepatic response to epinephrine in normal and diabetic man

  • L. Berman, A. H. Rubinstein
  • Clin . Res .
  • 1980

Effect of cardioselective and nonselective beta - blockade on the hypoglycaemic response in insulin - dependent diabetics

  • A. Aro, M. Pietikainen
  • Lancet .
  • 1979

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