Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.

@article{Myagmar2017AdrenergicRI,
  title={Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.},
  author={Bat-erdene Myagmar and James Flynn and Patrick M. Cowley and Philip M. Swigart and Megan Danielle Montgomery and Kevin Thai and Divya P. Nair and Rumita Gupta and David Xing-fei Deng and Chihiro Hosoda and Simon Melov and Anthony J. Baker and Paul C. Simpson},
  journal={Circulation research},
  year={2017},
  volume={120 7},
  pages={
          1103-1115
        }
}
RATIONALE It is unknown whether every ventricular myocyte expresses all 5 of the cardiac adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2 are thought to be the dominant myocyte ARs. OBJECTIVE Quantify the 5 cardiac ARs in individual ventricular myocytes. METHODS AND RESULTS We studied ventricular myocytes from wild-type mice, mice with α1A and α1B knockin reporters, and β1 and β2 knockout mice. Using individual isolated cells, we measured knockin reporters, mRNAs… CONTINUE READING

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