Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor

Abstract

To clarify the possible role of TNF and IL-1 in endotoxic shock, the lethality of rTNF (human and murine) and IL-1 in adrenalectomized mice was studied. Adrenalectomy, which has long been known to increase the susceptibility to endotoxin, rendered mice susceptible to TNF and IL-1 in terms of mortality. The lethality of endotoxin, TNF, or IL-1 was totally… (More)

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@article{Bertini1988AdrenalectomySM, title={Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor}, author={Roberto Bertini and M. Bianchi and Paolo Ghezzi}, journal={The Journal of Experimental Medicine}, year={1988}, volume={167}, pages={1708 - 1712} }