Adrenalectomy-induced apoptosis and glial responsiveness during ageing.

  title={Adrenalectomy-induced apoptosis and glial responsiveness during ageing.},
  author={Nicole Bye and Nancy R Nichols},
  volume={9 6},
Cell death by apoptosis occurs in mature neurones of adult rat dentate gyrus following adrenalectomy. In these studies, apoptosis in the dentate gyrus was induced 3 days after adrenalectomy in male Fischer 344 rats ranging in age from 2-3 to 24-26 months. Glial fibrillary acidic protein and transforming growth factor-beta 1 mRNAs were increased in dentate gyrus of all age groups after adrenalectomy, but there was no effect of age on these responses. Furthermore, corticosterone treatment in the… CONTINUE READING