Adrenalectomy attenuates stress-induced elevations in extracellular glutamate concentrations in the hippocampus.

@article{Lowy1993AdrenalectomyAS,
  title={Adrenalectomy attenuates stress-induced elevations in extracellular glutamate concentrations in the hippocampus.},
  author={Martin T. Lowy and L M Gault and Bryan K. Yamamoto},
  journal={Journal of neurochemistry},
  year={1993},
  volume={61 5},
  pages={1957-60}
}
Glucocorticoids and stress have deleterious effects on hippocampal cell morphology and survival. It has been hypothesized that these effects are mediated via an excitatory amino acid mechanism. The present study was designed to evaluate the effects of acute stress on the extracellular levels of glutamate in the hippocampus and to determine if adrenalectomy modifies this response. Rats were adrenalectomized or sham-adrenalectomized and implanted with microdialysis probes in the CA3 region of the… CONTINUE READING

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