Adrenal-mediated rather than direct effects of nicotine as a basis of altered sex steroid synthesis in fetal and neonatal rat.

@article{Sarasin2003AdrenalmediatedRT,
  title={Adrenal-mediated rather than direct effects of nicotine as a basis of altered sex steroid synthesis in fetal and neonatal rat.},
  author={Alexander Sarasin and Margret Schlumpf and Malvina M{\"u}ller and Ir{\`e}ne Fleischmann and Markus E Lauber and Walter Lichtensteiger},
  journal={Reproductive toxicology},
  year={2003},
  volume={17 2},
  pages={153-62}
}
Prenatal nicotine interferes with rat sexual brain differentiation and may influence human puberty. We studied effects of nicotine and cotinine on perinatal steroid synthesis in offspring of time-pregnant rats. In vitro, cotinine inhibited testosterone synthesis in neonatal rat testis. Both compounds inhibited the brain aromatase of gestational day (GD) 19 male fetuses. Effective concentrations were higher than levels in maternal plasma and fetal tissue at GD 19 after nicotine treatment from GD… CONTINUE READING
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