Adrenal gland enlargement in major depression. A computed tomographic study.

  title={Adrenal gland enlargement in major depression. A computed tomographic study.},
  author={Charles B. Nemeroff and K. Ranga R. Krishnan and David G. Reed and Richard Leder and Craig Beam and Nicholas Reed Dunnick},
  journal={Archives of general psychiatry},
  volume={49 5},
To determine whether the well-documented hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients includes adrenal gland hypertrophy, adrenal gland size was evaluated by computed tomography. Assessments consisted of (1) global ratings by two radiologists ignorant of the diagnostic identity of the subjects and (2) calculation of adrenal volume. Of the 38 patients with major depression, 12 were rated as exhibiting adrenal hypertrophy. Adrenal volumes in the depressed… CONTINUE READING


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