Adrenal cells in tissue culture. VIII. Dissociation of the steroidogenic and glycolytic effects of cyclic nucleotides and adrenocorticotropin

Abstract

In monolayer cultures of mouse adrenal cortex tumor cells, high concentrations of 3′,5′-cyclic adenosine monophosphate and 3′,5′-cyclic cytidine monophosphate (1.0 to 10.0mm produce steroidogenic responses equivalent to maximally stimulating levels of adrenocorticotropin. 3′,5′-Cyclic guanosine monophosphate and other cyclic nucleotides are not steroidogenic. Although the steroidogenic action of adrenocorticotropin is accompanied by an increased rate of glycolytic activity, the cyclic nucleotides stimulate steroidogenesis without increasing glycolysis. The data suggest that adrenocorticotropin can effect certain alterations in adrenal metabolism by a mechanism which does not involve the adenyl cyclase system.

DOI: 10.1007/BF02617761

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@article{Kowal1970AdrenalCI, title={Adrenal cells in tissue culture. VIII. Dissociation of the steroidogenic and glycolytic effects of cyclic nucleotides and adrenocorticotropin}, author={Justin Kowal}, journal={In Vitro}, year={1970}, volume={6}, pages={174-179} }