Adrenal androgen biosynthesis by a sesterpene pathway.

  title={Adrenal androgen biosynthesis by a sesterpene pathway.},
  author={Alexander D. Tait and L. C. Hodge},
  journal={Journal of steroid biochemistry},
  volume={30 1-6},
  • A. Tait, L. C. Hodge
  • Published 1988
  • Biology, Medicine, Chemistry
  • Journal of steroid biochemistry
6 Citations

Gas chromatographic and gas chromatographic/tandem mass spectrometric characterization of precursors on the sesterterpene pathway for steroid biosynthesis.

The present findings that sesterterpene pathway intermediates are present as endogenous compounds in tissue extracts, together with the previously reported radiochemical data, give further support to the sesterTERPene pathway hypothesis.

Hormonal dependence of human prostate tumors transplantable in nude mice : the importance of low androgen levels in prostate tumor growth

This thesis will contribute to a better understanding of the mechanisms of androgen regulated growth of human prostatic carcinoma which, together with the outcome of the necessary future experiments with human xenograft models, will result in a more effective treatment of patients with advanced prostatic cancer.

Biosynthesis of androgens by the sesterterpene pathway via 23,24-dinor-4-cholen-3-one

  • A. Tait
  • Chemistry, Biology
    The Journal of Steroid Biochemistry and Molecular Biology
  • 1992



Control of adrenal androgen secretion.

A correlation between the rhythmicity of secretion of cortisol and dehydroepiandrosterone (DHA) secretion in a normal volunteer was found, although the magnitude of the DHA rhythm was much less than that of cortisol.

Adrenal function in thalassemia major following long-term treatment with multiple transfusions and chelation therapy. Evidence for dissociation of cortisol and adrenal androgen secretion.

The results indicate that combined multiple transfusions and chelation therapy preserve the integrity of the ACTH-cortisol axis in patients with thalassemia, and the reduced levels of adrenal androgens, short stature, and delayed puberty noted in patients suggest, however, that alternative approaches to the therapy of thAlassemia are needed.

A 60,000 molecular weight human pituitary glycopeptide stimulates adrenal androgen secretion.

This new pituitary glycopeptide, with a molecular weight greater than that of proopiocortin, ACTH, PRL, or LH, may help explain instances during adrenarche, puberty, aging, and stress in which cortisol and adrenal androgen metabolism diverge.

The conversion of 23,24-dinor-chol-5-en-3 -ol into steroid hormones.

  • A. Tait
  • Chemistry
    The Biochemical journal
  • 1972
It is widely accepted that cholesterol is the precursor of the steroid hormones. However, there are reports suggesting that there could be some other pathway not involving cholesterol (Heard et al.,