Adrenal, kidney, and heart angiotensins in female murine Ren-2 transfected hypertensive rats.

@article{Senanayake1998AdrenalKA,
  title={Adrenal, kidney, and heart angiotensins in female murine Ren-2 transfected hypertensive rats.},
  author={Preenie S Senanayake and R R Smeby and Almir Souza Martins and Atsushi Moriguchi and Harumitsu Kumagai and Detlev Ganten and K. Bridget Brosnihan},
  journal={Peptides},
  year={1998},
  volume={19 10},
  pages={1685-94}
}
We analyzed by high-performance liquid chromatography and radioimmunoassay angiotensin I (Ang I), Ang II, Ang-(1-7), and metabolites in the adrenal, kidney and heart of normotensive female Sprague-Dawley (SD) and transgenic hypertensive [TGR(mRen-2)27] rats carrying the murine Ren-2d renin gene. The monogenetic model of hypertensive rats had significant increases in adrenal Ang II; whereas in the kidney Ang II was unchanged, but Ang I and Ang-(1-7) were significantly lower. Cardiac Ang I, Ang… CONTINUE READING

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