Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model.

@article{Zumwalde2017AdoptivelyTV,
  title={Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model.},
  author={Nicholas A Zumwalde and Akshat Sharma and Xuequn Xu and Shidong Ma and Christine L. Schneider and James C Romero-Masters and Amy W. Hudson and Annette P Gendron-Fitzpatrick and Shannon C. Kenney and Jenny E Gumperz},
  journal={JCI insight},
  year={2017},
  volume={2 13}
}
A central issue for adoptive cellular immunotherapy is overcoming immunosuppressive signals to achieve tumor clearance. While γδ T cells are known to be potent cytolytic effectors that can kill a variety of cancers, it is not clear whether they are inhibited by suppressive ligands expressed in tumor microenvironments. Here, we have used a powerful preclinical model where EBV infection drives the de novo generation of human B cell lymphomas in vivo, and autologous T lymphocytes are held in check… CONTINUE READING
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