Adoptive tumor therapy with T lymphocytes enriched through an IFN-γ capture assay

Abstract

Successful adoptive T-cell therapy has been demonstrated in viral disease and selected forms of cancer. However, it is limited by the difficulty to efficiently isolate and amplify autologous tumor-reactive T-cell clones. Tetramers of major histocompatibility complex (MHC) class I and peptide have facilitated the characterization of CD8+ T cells specific for… (More)
DOI: 10.1038/nm1001-1159

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