Adoptive-transfer therapy of tumors with the tumor-specific primary cytotoxic T cells induced in vitro with the B7.1-transduced MCA205 cell line

@article{Kim1999AdoptivetransferTO,
  title={Adoptive-transfer therapy of tumors with the tumor-specific primary cytotoxic T cells induced in vitro with the B7.1-transduced MCA205 cell line},
  author={Sun Jung Kim and Michel Sadelain and Jeong-soon Lee and Roh Hyun Seong and Y L Yun and Young Ju Jang and Hee Young Chung},
  journal={Cancer Immunology, Immunotherapy},
  year={1999},
  volume={47},
  pages={257-264}
}
We show that the tumor-specific primary cytotoxic T lymphocytes (CTL) induced in vitro with the MCA205 fibrosarcoma cells transduced with the B7.1 (CD80) gene are highly effective in adoptive-transfer therapy of the parental tumors. The MCA205 fibrosarcoma cell line was transduced with the retroviral vectors encoding the B7.1 gene and tested for their efficiency as stimulators in short-term (5 days) mixed lymphocyte/tumor cell cultures with highly purified syngenic, unprimed T cells as… CONTINUE READING

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