Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion.

@article{Powell2006AdoptiveTO,
  title={Adoptive transfer of vaccine-induced peripheral blood mononuclear cells to patients with metastatic melanoma following lymphodepletion.},
  author={Daniel James Powell and Mark Edward Dudley and Katherine A. Hogan and John R. Wunderlich and Steven A Rosenberg},
  journal={Journal of immunology},
  year={2006},
  volume={177 9},
  pages={6527-39}
}
Cancer vaccines can induce the in vivo generation of tumor Ag-specific T cells in patients with metastatic melanoma yet seldom elicit objective clinical responses. Alternatively, adoptive transfer of autologous tumor-infiltrating lymphocytes (TIL) can mediate tumor regression in 50% of lymphodepleted patients, but are logistically and technically difficult to generate. In this study, we evaluated the capability of vaccine-induced PBMC to mediate tumor regression after transfer to patients… CONTINUE READING