Adoptive immunotherapy of poorly immunogenic tumors with in vitro sensitized cells generated by intratumoral administration of biological response modifiers.

@article{Mukai1995AdoptiveIO,
  title={Adoptive immunotherapy of poorly immunogenic tumors with in vitro sensitized cells generated by intratumoral administration of biological response modifiers.},
  author={Satoshi Mukai and Hirokazu Kato and S Kimura and K Asai and Yutaka Kawahito and Masahiro Inoue and Yasuhiro Yamamura and Hiroyuki Sano and Shigeru Sugino and Sheng Rong Shu},
  journal={International journal of immunopharmacology},
  year={1995},
  volume={17 12},
  pages={
          963-71
        }
}
We investigated the efficacy of intratumoral administration of biological response modifiers (BRM) in induction of in vitro sensitized (IVS) cells for adoptive immunotherapy of the poorly immunogenic MCA 102 sarcoma and B16-BL6(BL6) melanoma. We used the bacterial immunoadjuvant Nocardia rubra cell wall skeleton (N-CWS), and a streptococcal preparation, OK-432, for MCA 102 and BL6, respectively. After C57BL/6(B6) mice were inoculated subcutaneously (s.c.) with viable MCA 102 or BL6 tumor cells… CONTINUE READING