Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms.

@article{Bagnara2009AdoptiveIM,
  title={Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms.},
  author={Davide Bagnara and Adalberto Ibatici and Mirko Corselli and Nadia Sessarego and Claudya Tenca and Amleto de Santanna and Andrea Nicola Mazzarello and Antonio Daga and Renzo Corv{\'o} and Giulio de Rossi and Francesco Frassoni and Ermanno 5 Ciccone and Franco Fais},
  journal={Haematologica},
  year={2009},
  volume={94 7},
  pages={967-74}
}
BACKGROUND CD1d is a monomorphic antigen presentation molecule expressed in several hematologic malignancies. Alpha-galactosylceramide (alpha-GalCer) is a glycolipid that can be presented to cytotoxic CD1d-restricted T cells. These reagents represent a potentially powerful tool for cell mediated immunotherapy. DESIGN AND METHODS We set up an experimental model to evaluate the use of adoptively transferred cytotoxic CD1d-restricted T cells and alpha-GalCer in the treatment of mice engrafted… CONTINUE READING
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