Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells.
@article{Till2008AdoptiveIF, title={Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells.}, author={B. Till and M. Jensen and Jinjuan Wang and Eric. Y. Chen and B. Wood and H. Greisman and Xiaojun Qian and S. James and A. Raubitschek and S. Forman and A. Gopal and J. Pagel and C. Lindgren and P. Greenberg and S. Riddell and O. Press}, journal={Blood}, year={2008}, volume={112 6}, pages={ 2261-71 } }
Adoptive immunotherapy with T cells expressing a tumor-specific chimeric T-cell receptor is a promising approach to cancer therapy that has not previously been explored for the treatment of lymphoma in human subjects. We report the results of a proof-of-concept clinical trial in which patients with relapsed or refractory indolent B-cell lymphoma or mantle cell lymphoma were treated with autologous T cells genetically modified by electroporation with a vector plasmid encoding a CD20-specific… CONTINUE READING
Supplemental Clinical Trials
Interventional Clinical Trial
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop
cancer cells from growing. Drugs used in chemotherapy use different ways to stop cancer cells… Expand
Conditions | Leukemia, Lymphoma |
---|---|
Intervention | Biological, Drug, Procedure |
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