Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study.

@article{Sakamoto2011AdoptiveIF,
  title={Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study.},
  author={Miki Sakamoto and Jun -Ichiro Nakajima and Tomohiro Murakawa and Takeshi Fukami and Yukihiro Yoshida and Tomonori Murayama and Shinichi Takamoto and Hirokazu Matsushita and Kazuhiro Kakimi},
  journal={Journal of immunotherapy},
  year={2011},
  volume={34 2},
  pages={
          202-11
        }
}
Human γδ T cells can recognize and kill non-small cell lung cancer (NSCLC) cells using the Vγ9Vδ2 T-cell receptor and/or NKG2D. We have established clinical grade large-scale ex vivo expansion of γδ T cells from peripheral blood mononuclear cells by culturing with zoledronate and interleukin-2 (IL-2). A phase I study was conducted to evaluate safety and potential antitumor effects of re-infusing ex vivo expanded γδ T cells in patients with recurrent or advanced NSCLC. Patient's peripheral blood… CONTINUE READING
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