Adoptive cell therapy using antigen-specific CD4−CD8− T regulatory cells to prevent autoimmune diabetes and promote islet allograft survival in NOD mice

@article{Zhang2011AdoptiveCT,
  title={Adoptive cell therapy using antigen-specific CD4−CD8− T regulatory cells to prevent autoimmune diabetes and promote islet allograft survival in NOD mice},
  author={Dongwei Zhang and Wenjing Zhang and Tony Chon Wee Ng and Yizhen Wang and Qing-rong Liu and Vikram Gorantla and F. Lakkis and Xin Xiao Zheng},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={2082-2092}
}
A new differentiation pathway for CD4−CD8− (DN) T cells has recently been identified that exhibits the potent function of peripheral converted DN T cells in suppressing immune responses and provides the potential to treat autoimmune diseases. The aim of this study was to determine if the DN T cells converted from CD4+ T cells of NOD mice retain the antigen-specific regulatory capacity and prevent autoimmune diabetes in vivo. We also sought to determine if the combination of DN T cells with… CONTINUE READING
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The DN T cells from NOD donors blocked autoimmunity and prevented diabetes in NOD models , and these effects were even greater for GAD65-peptide - primed DN T cells .
The DN T cells from NOD donors blocked autoimmunity and prevented diabetes in NOD models , and these effects were even greater for GAD65-peptide - primed DN T cells .
The antigen - specific DN T cells were adoptively transferred to NOD / SCID mice , new - onset diabetic NOD mice or islet - allograft - recipient NOD mice as the part of cell - based therapy .
We also sought to determine if the combination of DN T cells with rapamycin promotes islet allograft survival in autoimmune diabetic NOD recipients .
The antigen - specific DN T cells were adoptively transferred to NOD / SCID mice , new - onset diabetic NOD mice or islet - allograft - recipient NOD mice as the part of cell - based therapy .
The antigen - specific DN T cells were adoptively transferred to NOD / SCID mice , new - onset diabetic NOD mice or islet - allograft - recipient NOD mice as the part of cell - based therapy .
The DN T cells from NOD donors blocked autoimmunity and prevented diabetes in NOD models , and these effects were even greater for GAD65-peptide - primed DN T cells .
The antigen - specific DN T cells were adoptively transferred to NOD / SCID mice , new - onset diabetic NOD mice or islet - allograft - recipient NOD mice as the part of cell - based therapy .
We also sought to determine if the combination of DN T cells with rapamycin promotes islet allograft survival in autoimmune diabetic NOD recipients .
The DN T cells from NOD donors blocked autoimmunity and prevented diabetes in NOD models , and these effects were even greater for GAD65-peptide - primed DN T cells .
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