Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice

@inproceedings{Jing2017AdoptiveCT,
  title={Adoptive cell therapy using PD-1+ myeloma-reactive T cells eliminates established myeloma in mice},
  author={Weiqing Jing and Jill A. Gershan and Grace C. Blitzer and Katie A. Palen and James J. Weber and Laura McOlash and Matthew J. Riese and Bryon D. Johnson},
  booktitle={Journal for ImmunoTherapy of Cancer},
  year={2017}
}
BackgroundAdoptive cellular therapy (ACT) with cancer antigen-reactive T cells following lymphodepletive pre-conditioning has emerged as a potentially curative therapy for patients with advanced cancers. However, identification and enrichment of appropriate T cell subsets for cancer eradication remains a major challenge for hematologic cancers.MethodsPD-1+ and PD-1− T cell subsets from myeloma-bearing mice were sorted and analyzed for myeloma reactivity in vitro. In addition, the T cells were… CONTINUE READING
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