Adoptive cell therapy for the treatment of patients with metastatic melanoma.

@article{Rosenberg2009AdoptiveCT,
  title={Adoptive cell therapy for the treatment of patients with metastatic melanoma.},
  author={Steven A Rosenberg and Mark Edward Dudley},
  journal={Current opinion in immunology},
  year={2009},
  volume={21 2},
  pages={
          233-40
        }
}
Adoptive cell therapy (ACT) is the best available treatment for patients with metastatic melanoma. In a recent series of three consecutive clinical trials using increasing lymphodepletion before infusion of autologous tumor infiltrating lymphocytes (TIL), objective response rates between 49% and 72% were seen. Persistence of infused cells in the circulation at one month was highly correlated with anti-tumor response as was the mean telomere length of the cells infused and the number of CD8… CONTINUE READING
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Tumor-specific IL-9-producing CD8+ Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers.

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