Adoptive cell therapy: past, present and future.

  title={Adoptive cell therapy: past, present and future.},
  author={Jane Cohen and Sharon Merims and Stephen Jay Frank and Roni Engelstein and Tamar Y. Peretz and Michal Lotem},
  volume={9 2},
The immune system is a potent inhibitor of tumor growth with curative potential, constituting in many eyes the future of antineoplastic therapy. Adoptive cell therapy (ACT) is a form of immunotherapy in which autologous cancer-cognate lymphocytes are expanded and modified ex vivo and re-infused to combat the tumor. This review follows the evolvement of ACT and treatment protocols, focusing on unresolved dilemmas regarding this treatment while providing evidence for its effectiveness in… CONTINUE READING

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