Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT.

@article{Feucht2015AdoptiveTT,
  title={Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT.},
  author={Judith Feucht and Kathrin Opherk and Peter A. Lang and Simone Kayser and Lena Hartl and Wolfgang Andreas Bethge and Susanne Matthes-Martin and Peter Bader and Michael H. Albert and Britta Maecker-Kolhoff and Johann Greil and Hermann Einsele and Paul Gerhardt Schlegel and Friedhelm R. Schuster and Bernhard Kremens and Claudia Rossig and Bernd Gruhn and Rupert Handgretinger and Tobias Feuchtinger},
  journal={Blood},
  year={2015},
  volume={125 12},
  pages={1986-94}
}
Hematopoietic stem cell transplantation (HSCT) has improved over the last few decades. However, viral infections are often refractory to pharmacologic treatment and require alternative treatment strategies such as immunotherapy. Adenovirus (AdV) is th predominant disease-causing pathogen in pediatric HSCT. In a clinical trial, we analyzed safety and efficacy of ex vivo adoptive T-cell transfer (ACT) with hexon-specific T cells, predominantly of the T-helper cell 1 (Th1) phenotype, in 30… CONTINUE READING
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Fourth European Conference on Infections in Leukemia. European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary

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