Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy.

@article{Brestrich2009AdoptiveTT,
  title={Adoptive T-cell therapy of a lung transplanted patient with severe CMV disease and resistance to antiviral therapy.},
  author={Gordon Brestrich and Sandra Zwinger and Andr{\'e} Fischer and Michael Schmueck and A R{\"o}hmhild and Markus H. Hammer and Andreas Kurtz and Lutz Uharek and Christoph Knosalla and Hans Lehmkuhl and H D Volk and Petra Reinke},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2009},
  volume={9 7},
  pages={
          1679-84
        }
}
Infections with cytomegalovirus (CMV) can induce severe complications after transplantation, particularly in patients resistant to virostatic therapy. Adoptive transfer of CMV-specific T-cell lines has demonstrated promising results in patients after hematopoietic stem cell transplantation. However, the generation of specific T-cell lines ex vivo and their function in vivo is complicated in solid organ transplant (SOT) recipients. Here, we present the successful adoptive transfer of autologous… CONTINUE READING
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