Adoption of an “Open” Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch in R5 SHIV-Infected Macaques

@inproceedings{Zhuang2011AdoptionOA,
  title={Adoption of an “Open” Envelope Conformation Facilitating CD4 Binding and Structural Remodeling Precedes Coreceptor Switch in R5 SHIV-Infected Macaques},
  author={Ke Zhuang and Andr{\'e}s Finzi and Silvana Tasca and Madina Shakirzyanova and Heather Knight and Susan Westmoreland and Joseph Sodroski and Cecilia Cheng-Mayer},
  booktitle={PloS one},
  year={2011}
}
A change in coreceptor preference from CCR5 to CXCR4 towards the end stage disease in some HIV-1 infected individuals has been well documented, but the reasons and mechanisms for this tropism switch remain elusive. It has been suggested that envelope structural constraints in accommodating amino acid changes required for CXCR4 usage is an obstacle to tropism switch, limiting the rate and pathways available for HIV-1 coreceptor switching. The present study was initiated in two R5 SHIV(SF162P3N… CONTINUE READING

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Effect of Bcell-depletion on coreceptor switching in R5 SHIVinfection of rhesus macaques

S Tasca, K Zhuang, A Gettie, H Knight, J Blanchard
J Virol: doi:10.1128/JVI.021510-021510 • 2011
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