Adolescents with major depression demonstrate increased amygdala activation.

@article{Yang2010AdolescentsWM,
  title={Adolescents with major depression demonstrate increased amygdala activation.},
  author={Tony T. Yang and Alan N. Simmons and Scott C. Matthews and Susan F. Tapert and Guido K W Frank and Jeffrey E Max and Amanda Bischoff-Grethe and Amy E. Lansing and Gregory Brown and Irina A Strigo and Jing Wu and Martin P. Paulus},
  journal={Journal of the American Academy of Child and Adolescent Psychiatry},
  year={2010},
  volume={49 1},
  pages={42-51}
}
OBJECTIVE Functional neuroimaging studies have led to a significantly deeper understanding of the underlying neural correlates and the development of several mature models of depression in adults. In contrast, our current understanding of the underlying neural substrates of adolescent depression is very limited. Although numerous studies have consistently demonstrated a hyperactive amygdala in depressed adults, the few published pediatric studies have reported opposite results in the amygdala… CONTINUE READING

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