Adolescent toluene exposure produces enduring social and cognitive deficits in mice: an animal model of solvent-induced psychosis.

@article{Lin2010AdolescentTE,
  title={Adolescent toluene exposure produces enduring social and cognitive deficits in mice: an animal model of solvent-induced psychosis.},
  author={Bih-Fen Lin and M C Ou and Shiang-Sheng Chung and C. Y. Amy Pang and H. -H. Chen},
  journal={The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry},
  year={2010},
  volume={11 6},
  pages={792-802}
}
OBJECTIVES Abuse of toluene-containing volatile solvents by adolescents is a significant public health problem. The present study characterized the long-term behavioural and neurochemical consequences of toluene exposure during adolescence. METHODS Male NMRI mice received one injection per day of either toluene (600 mg/kg) or corn oil during postnatal days (PN) 35-37 and (750 mg/kg) during PN38-39 and PN42-46. A variety of psychiatric disorder-relevant behavioural tests were examined at PN56… CONTINUE READING
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