Adolescent exposure to cannabinoids induces long-Lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons

@article{Pistis2004AdolescentET,
  title={Adolescent exposure to cannabinoids induces long-Lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons},
  author={Marco Pistis and Simona Perra and G. Pillolla and Miriam Melis and Anna Lisa Muntoni and Gian Luigi Gessa},
  journal={Biological Psychiatry},
  year={2004},
  volume={56},
  pages={86-94}
}
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189 Citations
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Findings—that early, passive exposure to THC can produce lasting alterations of the reward system of the brain and subsequently increase cannabinoid self-administration in adulthood—suggest a mechanism by which adolescent cannabis exposure could increase the risk of subsequent cannabis dependence in humans.

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Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates

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The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.

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TLDR
The prepubertal developmental phase, in addition to puberty, also represents a vulnerable time period for persistent adverse effects of cannabinoids, based on the observations of sensorimotor gating deficits and increased anxiety in adult rats.

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TLDR
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TLDR
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Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine

TLDR
It is demonstrated that a history of synthetic cannabinoid exposure in adolescent animals results in distinct molecular and epigenetic changes following initial exposure to cocaine, which are pronounced in the prefrontal cortex and associated with an enhanced response to cocaine’s stimulatory effects.
...

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