Adolescent exposure to cannabinoids induces long-Lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons

@article{Pistis2004AdolescentET,
  title={Adolescent exposure to cannabinoids induces long-Lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons},
  author={Marco Pistis and Simona Perra and G. Pillolla and Miriam Melis and Anna Muntoni and Gian Luigi Gessa},
  journal={Biological Psychiatry},
  year={2004},
  volume={56},
  pages={86-94}
}
BACKGROUND Recent studies have raised concerns about subtle long-lasting neurobiological changes that might be triggered by exposure to Cannabis derivatives, especially in a critical phase of brain maturation, such as puberty. The mesolimbic dopamine (DA) system, involved in the processing of drug-induced reward, is a locus of action of cannabinoids and endocannabinoids. Thus, we compared the effects of repeated cannabinoid administration in adolescent and adult rats on DA neuronal functions… CONTINUE READING
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