Adolescent depression: A placebo-controlled fluoxetine treatment study and follow-up

@article{Simeon1990AdolescentDA,
  title={Adolescent depression: A placebo-controlled fluoxetine treatment study and follow-up},
  author={Jovan G. Simeon and Vincenzo F. Dinicola and H. Bruce Ferguson and Warren Copping},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1990},
  volume={14},
  pages={791-795}
}

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Paroxetine demonstrated significantly greater improvement compared with placebo in Hamilton Rating Scale for Depression total score < or = 8, HAM-D depressed mood item, K-SADS-L depressed Mood item, and CGI score of 1 or 2.

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Adolescent depression: Controlled desipramine treatment and atypical features

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...

References

SHOWING 1-8 OF 8 REFERENCES

Fluoxetine versus trazodone in the treatment of outpatients with major depression.

Fluoxetine and trazodone were compared in a double-blind, randomized, parallel, 6-week trial in 43 outpatients with major depression after a 1-week single-blind placebo period. Thirty-five patients

A fixed-dose clinical trial of fluoxetine in outpatients with major depression.

The 20-mg dose produced improvement of depression in the moderate-severe depression group as expressed in significant reductions of scores on the Hamilton Rating Scale for Depression and the Patient Global Impressions scale.

A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder.

Fluoxetine had significantly less associated anticholinergic effects, dizziness, drowsiness, somatosensory disturbance, and excessive sweating than imipramine, and although nausea occurred more frequently in fluoxettine patients, it was generally mild and well tolerated.

Depressive disorders in children and adolescents.

  • Sim Jg
  • Psychology, Medicine
  • 1989
Open drug studies suggest that antidepressants are useful in depressed children andPolysomnographic findings in childhood depression appear unremarkable and in adolescent depression these findings are similar to those in depressed adults.

Impact of severity and chronicity of parental affective illness on adaptive functioning and psychopathology in children.

Almost every measure of severity and chronicity of depression in the biological parents has a statistically significant association with currently impaired adaptation and the presence of a DSM-III-diagnosed disorder in the children, as do the measures of increased discord among married or separated parents.

The Hopkins Symptom Checklist (HSCL): a self-report symptom inventory.

The historical evolution, development, rationale and validation of the Hopkins Symptom Checklist is described, a self-report symptom inventory comprised of 58 items which are representative of the symptom configurations commonly observed among outpatients.

Development of a rating scale for primary depressive illness.

  • M. Hamilton
  • Psychology
    The British journal of social and clinical psychology
  • 1967
This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of