Adolescent binge alcohol exposure alters hippocampal progenitor cell proliferation in rats: effects on cell cycle kinetics.

@article{McClain2011AdolescentBA,
  title={Adolescent binge alcohol exposure alters hippocampal progenitor cell proliferation in rats: effects on cell cycle kinetics.},
  author={Justin A. McClain and Dayna M. Hayes and Stephanie A. Morris and Kimberly Nixon},
  journal={The Journal of comparative neurology},
  year={2011},
  volume={519 13},
  pages={2697-710}
}
Binge alcohol exposure in adolescent rats potently inhibits adult hippocampal neurogenesis by altering neural progenitor cell (NPC) proliferation and survival; however, it is not clear whether alcohol results in an increase or decrease in net proliferation. Thus, the effects of alcohol on hippocampal NPC cell cycle phase distribution and kinetics were assessed in an adolescent rat model of an alcohol use disorder. Cell cycle distribution was measured using a combination of markers (Ki-67… CONTINUE READING