Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy. A study of 293 patients.

@article{Baccarani1982AdolescentAA,
  title={Adolescent and adult acute lymphoblastic leukemia: prognostic features and outcome of therapy. A study of 293 patients.},
  author={Michele Baccarani and Giovanna Corbelli and S. Amadori and A M Drenthe-Schonk and Roel Willemze and Giovanna Meloni and P L Cardozo and Clemens Haanen and Franco Mandelli and Sante Tura},
  journal={Blood},
  year={1982},
  volume={60 3},
  pages={677-84}
}
The case histories of 293 adolescent and adult patients with acute lymphoblastic leukemia (ALL) first seen and treated between 1969 and 1979 are reviewed. A complete remission (CR) was achieved in 79% of cases. Male sex, advanced age (greater than or equal to 30 yr old), and early CNS involvement were the major determinants of remission failure. Median duration of first CR was 16 mo, with 23 patients (actuarial proportion 25%) alive and relapse-free at 5 yr. The major determinant of first CR… CONTINUE READING