Admixture of a recombinant vaccinia virus containing the gene for the costimulatory molecule B7 and a recombinant vaccinia virus containing a tumor-associated antigen gene results in enhanced specific T-cell responses and antitumor immunity.

@article{Hodge1995AdmixtureOA,
  title={Admixture of a recombinant vaccinia virus containing the gene for the costimulatory molecule B7 and a recombinant vaccinia virus containing a tumor-associated antigen gene results in enhanced specific T-cell responses and antitumor immunity.},
  author={James W Hodge and James P McLaughlin and Scott I Abrams and W. Lesley Shupert and Jeffrey Schlom and Judith A. Kantor},
  journal={Cancer research},
  year={1995},
  volume={55 16},
  pages={3598-603}
}
At least two signals are required for the activation of naive T cells by antigen-bearing target cells: an antigen-specific signal, delivered through the T-cell receptor, and a costimulatory signal delivered through the T-cell surface molecule CD28 by its natural ligand B7-1. The immunological benefit of coexpression of B7 with target antigen has been… CONTINUE READING