Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

@article{Reich2007AdmixtureMO,
  title={Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.},
  author={David Reich and Nick Patterson and V Ramakrishnan Ramesh and Philip L De Jager and Gavin J. McDonald and Arti Tandon and Edwin Choy and Donglei Hu and Bani Tamraz and Ludmila Pawlikowska and Christina L Wassel-Fyr and Scott Huntsman and Alicja I Waliszewska and Elizabeth Rossin and Rongling Li and Melissa J Garcia and Alex P. Reiner and Robert F. Ferrell and Steve Cummings and Pui-Yan Kwok and Tamara M Harris and Joseph M. Zmuda and Elad Ziv},
  journal={American journal of human genetics},
  year={2007},
  volume={80 4},
  pages={716-26}
}
Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms (SNPs) in 1,184 African Americans from the Health, Aging and Body Composition (Health ABC) Study. Using admixture mapping, we found a significant association of interleukin 6 soluble receptor (IL-6 SR) with European ancestry on chromosome 1 (LOD 4.59), in a region that includes the gene for this receptor… CONTINUE READING