Admixture in Mexico City: implications for admixture mapping of Type 2 diabetes genetic risk factors

@article{MartnezMarignac2006AdmixtureIM,
  title={Admixture in Mexico City: implications for admixture mapping of Type 2 diabetes genetic risk factors},
  author={V. Mart{\'i}nez-Marignac and A. Valladares and E. Cameron and A. Chan and Arjuna Perera and Rachel Globus-Goldberg and N. Wacher and J. Kumate and P. McKeigue and David O'donnell and M. Shriver and M. Cruz and E. Parra},
  journal={Human Genetics},
  year={2006},
  volume={120},
  pages={807-819}
}
Admixture mapping is a recently developed method for identifying genetic risk factors involved in complex traits or diseases showing prevalence differences between major continental groups. Type 2 diabetes (T2D) is at least twice as prevalent in Native American populations as in populations of European ancestry, so admixture mapping is well suited to study the genetic basis of this complex disease. We have characterized the admixture proportions in a sample of 286 unrelated T2D patients and 275… Expand
A genomewide admixture mapping panel for Hispanic/Latino populations.
TLDR
This report reports a genomewide AM panel with 2,120 AIMs showing high frequency differences between Native American and European populations, which will make it possible to apply AM approaches in many admixed populations throughout the Americas. Expand
Ancestry informative markers and admixture proportions in northeastern Mexico
TLDR
The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers (∼78%), compared with Amerindian and African markers (10%). Expand
Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes
TLDR
The proportion of non-European ancestry is associated with both type 2 diabetes and lower socioeconomic status in admixed Latino populations from North and South America, and ancestry-directed search for genetic markers associated with type 1 diabetes in Latinos may benefit from information involving social factors. Expand
Admixture mapping comes of age.
TLDR
A historical perspective is provided, AIM panels and software packages are reviewed, and recent successes and unexpected insights into human diseases that exhibit disparate rates across human populations are discussed. Expand
A genomewide admixture map for Latino populations.
TLDR
A advantage of the strategy is that the map focused on markers distinguishing Native American from other ancestries and restricted it to markers with very similar frequencies in Europeans and Africans, which decreased the number of markers needed and minimized the possibility of false disease associations. Expand
Ancestry Informative Markers Clarify the Regional Admixture Variation in the Costa Rican Population
TLDR
Though the authors did not find stratification in Costa Rica's population, gene admixture should be evaluated in future genetic studies of Costa Rica, especially for the Caribbean region, as it contains the largest proportion of African ancestry (30.9%). Expand
Genetic admixture, self-reported ethnicity, self-estimated admixture, and skin pigmentation among Hispanics and Native Americans.
TLDR
Within Hispanics, genetic-marker estimated admixture is better predicted by forehead skin pigmentation than by self-estimated admixture, and this results highlight the interplay between culture and biology in how individuals identify and view themselves, and have implications for how ethnicity and disease risk are assessed in a medical setting. Expand
Admixture and population structure in Mexican-Mestizos based on paternal lineages
TLDR
A strong gender-biased admixture history between European males and Native American females that gave rise to Mexican-Mestizos is confirmed and is in agreement with historical records. Expand
Genetic admixture, relatedness, and structure patterns among Mexican populations revealed by the Y-chromosome.
TLDR
Y-linked markers are suitable loci to analyze genetic diversity of human populations, offering knowledge of medical, forensic, and anthropological interest, and adding to the analysis data of Mexican Mestizos and Amerindians, and relevant worldwide populations. Expand
Heterogeneity in Genetic Admixture across Different Regions of Argentina
TLDR
The results demonstrate the range of variation in genetic ancestry among Argentine individuals from different regions in the country, highlighting the importance of taking this variation into account in genetic association and admixture mapping studies in this population. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
A high-density admixture map for disease gene discovery in african americans.
TLDR
This map provides a practical and powerful tool, which is freely available without restriction, for screening for disease genes in African American patient cohorts, and is especially appropriate for those diseases that differ in incidence between the parental African and European populations. Expand
Admixture in the Hispanics of the San Luis Valley, Colorado, and its implications for complex trait gene mapping
Hispanic populations are a valuable resource that can and should facilitate the identification of complex trait genes by means of admixture mapping (AM). In this paper we focus on a particularExpand
Relation of type 2 diabetes to individual admixture and candidate gene polymorphisms in the Hispanic American population of San Luis Valley, Colorado
TLDR
It is now possible to identify relatively large numbers of ancestry informative markers from data accumulating in the public domain, and a panel of 21 markers chosen to have large differences in frequency between European, Native American, and West African ancestry is typed. Expand
Prospects for admixture mapping of complex traits.
  • P. McKeigue
  • Biology, Medicine
  • American journal of human genetics
  • 2005
TLDR
Statistical-analysis programs for admixture mapping are now available, and a genomewide panel of markers for admixtures mapping in populations formed by West African-European admixture has been assembled. Expand
Measuring and using admixture to study the genetics of complex diseases
TLDR
Methods to detect and control for stratification in case/control and AM studies are reviewed, along with recent studies showing individual ancestry-phenotype correlations. Expand
Design and analysis of admixture mapping studies.
TLDR
It is shown that 60% of information can be extracted in a test for linkage using markers with an ancestry information content of 36% at 3-cM spacing, and that the most efficient strategy is to use markers at a moderate density for an initial genome search and then to saturate regions of putative linkage with additional markers, to extract nearly all information about locus ancestry. Expand
Methods for high-density admixture mapping of disease genes.
Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) has been proposed as an efficient approach to localizing disease-causing variants that differ in frequencyExpand
Admixture analysis of a rural population of the state of Guerrero, Mexico.
TLDR
The results show that the population of Tlapa in Guerrero, Mexico, has experienced little admixture with Europeans and/or West Africans and that heterogeneity is a major characteristic of Mexican populations and should not be disregarded when designing epidemiological studies of Mexican and Mexican American populations. Expand
Estimating African American admixture proportions by use of population-specific alleles.
TLDR
Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population. Expand
Admixture mapping as a gene discovery approach for complex human traits and diseases
TLDR
It is concluded that AM has potential in the identification of disease-predisposing loci, but this potential may only exist in a limited number of realistic settings. Expand
...
1
2
3
4
5
...