Admixture in Mexico City: implications for admixture mapping of Type 2 diabetes genetic risk factors

  title={Admixture in Mexico City: implications for admixture mapping of Type 2 diabetes genetic risk factors},
  author={Ver{\'o}nica L. Mart{\'i}nez-Marignac and Ad{\'a}n Valladares and Emily Cameron and Andrea Chan and Arjuna Perera and Rachel Globus-Goldberg and Niels H Wacher and Jes{\'u}s Kumate and Paul M. McKeigue and David O'donnell and Mark David Shriver and Miguel Cruz and Esteban Juan Parra},
  journal={Human Genetics},
Admixture mapping is a recently developed method for identifying genetic risk factors involved in complex traits or diseases showing prevalence differences between major continental groups. Type 2 diabetes (T2D) is at least twice as prevalent in Native American populations as in populations of European ancestry, so admixture mapping is well suited to study the genetic basis of this complex disease. We have characterized the admixture proportions in a sample of 286 unrelated T2D patients and 275… 

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DNA markers, such as D1S80 and HLA‐DQA1, are useful for examining genetic homogeneity/heterogeneity across Mestizo populations of Mexico, and the inverse relationship of the proportion of gene diversity due to population differences to within population gene diversity is consistent with theoretical predictions, supporting the use of these markers for population genetics studies.

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It is argued that morphological traits are of limited use in resolving current problems of human admixture studies and should be made from in-depth investigations of historical demography and social structure of admixed populations.