Admixture Estimates for Caracas, Venezuela, Based on Autosomal, Y-Chromosome, and mtDNA Markers

  title={Admixture Estimates for Caracas, Venezuela, Based on Autosomal, Y-Chromosome, and mtDNA Markers},
  author={Helios De Rosario Mart{\'i}nez and A. Rodriguez-Larralde and Mary Helen Izaguirre and Dinorah Castro de Guerra},
  booktitle={Human biology},
ABSTRACT The present Venezuelan population is the product of admixture of Amerindians, Europeans, and Africans, a process that was not homogeneous throughout the country. Blood groups, short tandem repeats (STRs), mtDNA, and Y-chromosome markers have been used successfully in admixture studies, but few such studies have been conducted in Venezuela. In this study we aim to estimate the admixture components of samples from two different socio -economic levels from Caracas, Venezuela's capital… 

Gender Differences in Ancestral Contribution and Admixture in Venezuelan Populations

The genome of paternal heredity shows a homogeneous pattern of admixture that is independent of the origin of the population studied, suggesting that European genes have been introduced into the Venezuelan population through male immigrations, whereas the indigenous contribution has been preserved in the Venezuelan genetic pool through the women.

A melting pot of multicontinental mtDNA lineages in admixed Venezuelans.

The native American component of admixed Venezuelans accounted for 80% of all mtDNAs; while the sub-Saharan and European contributions made up ∼10% each, indicating that Trans-Atlantic immigrants have only partially erased the native American nature of Venezuelans.

ComposiCión genétiCa de una poblaCión del suroccidente de Colombia

The mtDNA and the Y chromosome data, indicate a strong sexual bias (asymmetrical gene flow) in the admixing process, where interethnic crosses were mainly between European men and native women.

Ancestría genética y estratificación social en Montevideo, Uruguay

Investigating the genetic origin of the population of Montevideo using a sample derived from a previously published study, in which different factors that could influence ancestry estimations focused in particular on Native American and African contributions.

Demand for larger Y-STR reference databases in ethnic melting-pot countries: Argentina as a test case

This work proposes organizing Y-STR haplotype reference databases according to the most frequent haplogroups detected in a given admixed population, probably due to the different proportions of the Native American Q3-M3 haplogroup in the studied samples.

Human sociogenetics.

This SGC seems to be present in societies with a hierarchical organization in relation to power, prestige, ownership, income and life style, and when sampling includes the most extreme SES, and has not been found in two samples from Ireland and in a sample from Chile taken from a public hospital.

Genetic diversity in Puerto Rico and its implications for the peopling of the Island and the West Indies.

To infer patterns of pre-Columbian and historic peopling of the Caribbean, genetic diversity in 326 individuals from the southeastern region of Puerto Rico and the island municipality of Vieques was characterized, attest to the distinct, yet equally complex, past for the male and female ancestors of modern day Puerto Ricans.

Inference of recent admixture using genotype data

This work improves statistical methods as used in STRUCTURE and ADMIXTURE for Biogeographical Ancestry (BGA) inference to account for recent admixture, i.e. different admixture of both parents, which has a higher accuracy in estimating individual admixture in most cases.

Distribution of CYP2C19*2 and CYP2C19*3 polymorphisms in Venezuelan populations with different admixture

CYP2C19 polymorphisms in the Venezuelan general population are evaluated for the first time to suggest that the presence of alleles CYP2C 19*2 and CYP1C19*3 is associated with the indigenous component in the Venezuelan populations studied.



Characterization of Admixture in an Urban Sample from Buenos Aires, Argentina, Using Uniparentally and Biparentally Inherited Genetic Markers

Most of the individuals from La Plata with a native American mtDNA haplogroup or the DYS199*T native American allele show a genetic contribution at the autosomal level that can be traced primarily to Europe.

Mitochondrial DNA Analysis in Aruba : Strong Maternal Ancestry of Closely Related Amerindians and Implications for the Peopling of Northwestern Venezuela

It is hypothesized that the frequency of haplogroup D mtDNAs should be high in the Caquetı́o tribe of coastal Falcón in Venezuela and at least moderate in the Guajiro Indians of eastern Colombia, and that the native Aruban Indians contributed substantially to the current mtDNA pool of Arubans despite the repeated historical deportation events that presumably removed the complete populations from the island.

Microsatellite variation in Central Africa: an analysis of intrapopulational and interpopulational genetic diversity.

The analysis of association between genotypes at pairs of independent loci indicates that the level of subheterogeneity is markedly lower in the Bamileke than in other sampled populations, which may be explained by the combined effect of larger population size, more rigid respect of clanic exogamy, and higher matrimonial mobility of the Bamileske.

Ribeiro's typology, genomes, and Spanish colonialism, as viewed from Gran Canaria and Colombia

This analysis showed a usual trend in the Spanish Colonial history, characterized by a demographic collapse of the aboriginal population, but with considerable introgression of genes through native women.

Admixture studies in Latin America: from the 20th to the 21st century.

From these studies it is possible to conclude that Amerindian admixture came mainly from female lineages, but it is difficult to establish what happened with the African contribution.

Comparison of allele frequencies of eight STR loci from Argentinian Amerindian and European populations.

FST and G tests demonstrated that significant differences exist among the investigated populations for some of the eight STRs markers, suggesting non-Amerindian admixture.

Recent male-mediated gene flow over a linguistic barrier in Iberia, suggested by analysis of a Y-chromosomal DNA polymorphism.

Evidence for direct or indirect gene flow over the substantial linguistic barrier between the Indo-European and non-Indo-European-speaking populations of the Catalans and the Basques, during the past few thousand years is provided.

The ancestry of Brazilian mtDNA lineages.

The mtDNA pool of present-day Brazilians clearly reflects the imprints of the early Portuguese colonization process (involving directional mating), as well as the recent immigrant waves (from Europe) of the last century.

Genetic variation among four Mexican populations (Huichol, Purepecha, Tarahumara, and Mestizo) revealed by two VNTRs and four STRs.

Correlation between the observed genetic features and the geographic isolation level points to genetic drift as the main cause of differentiation among these Mexican populations.