Administration to mouse of endotoxin from gram-negative bacteria leads to activation and apoptosis of T lymphocytes.

@article{Castro1998AdministrationTM,
  title={Administration to mouse of endotoxin from gram-negative bacteria leads to activation and apoptosis of T lymphocytes.},
  author={Arturo Castro and Veronique Bemer and Alberto N{\'o}brega and Ant{\'o}nio Coutinho and P Truffa-bachi},
  journal={European journal of immunology},
  year={1998},
  volume={28 2},
  pages={488-95}
}
Lipopolysaccharide (LPS) from gramnegative bacteria is a well-known T cell-independent B lymphocyte mitogen and macrophage/monocyte activator. While the conventional view holds that LPS is ignored by T cells, we report here that administration of LPS to mice activates all B cells, but also engages most CD4 and CD8 T cells, as measured by the expression of… CONTINUE READING