Administration of tyrosyl radical-oxidized HDL inhibits the development of atherosclerosis in apolipoprotein E-deficient mice.

@article{Macdonald2003AdministrationOT,
  title={Administration of tyrosyl radical-oxidized HDL inhibits the development of atherosclerosis in apolipoprotein E-deficient mice.},
  author={Dawn L. Macdonald and T L Terry and Luis B. Agellon and Patrick N. Nation and Gordon A. Francis},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 9},
  pages={
          1583-8
        }
}
OBJECTIVE Tyrosyl radical-oxidized HDL (tyrHDL) increases the ability of cells to donate cholesterol to apolipoprotein (apo) A-I for HDL particle formation. We tested whether treatment with tyrHDL raises endogenous HDL cholesterol levels and decreases atherosclerosis development in apoE-deficient mice. METHODS AND RESULTS Tyrosyl radical oxidation of mouse HDL induced formation of apoAI-AII heterodimers and enhanced the ability of mouse HDL to deplete cultured fibroblasts of their regulatory… CONTINUE READING

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