Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis.

@article{Alexander2003AdministrationOT,
  title={Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis.},
  author={Jessy John Alexander and Lihua Bao and Alexander Philip Jacob and Damien M Kraus and V. Michael Holers and Richard J Quigg},
  journal={Biochimica et biophysica acta},
  year={2003},
  volume={1639 3},
  pages={169-76}
}
Changes in brain water and cerebral volume can lead to brain edema that may be one of the underlying causes of death in many neurological diseases. Cerebral water content is regulated by aquaporin 4 (AQ4) present in astrocytic end feet and around blood vessels. In systemic lupus erythematosus (SLE), magnetic resonance imaging (MRI) studies of the brain have demonstrated lesions with the prominent appearance of edema. Activation of complement may play a significant role in the pathogenesis of… CONTINUE READING
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